Thursday, March 14, 2013

plasma proteins

1- Name the major proteins of plasma.
(Albumin, Globulin and Fibrinogen)
2-Name the transport proteins
(Albumin, Lipoproteins, Prealbumin, Transthyretin, Retinol Binding protein, Thyroxin binding Globulin)
3-How many copper atoms can bind to one molecule of ceruloplasmin?
4-What is A: G ratio, what is its range in the normal health?                  
(1.2:1 to 1.5:1)
5-What is the most significant sign of hypoproteinemia?
6-Almost all proteins except Globulins are synthesized in the liver, True or false?
7-Name the negative phase proteins
(Albumin, Transthyretin, Transferrin etc.)
8-What are the different types of light chains?
( Kappa and Lambda)
9-Which immunoglobulin is the major antibody of primary immune response
10-What is the function of the secretory piece of the IgA?
(It protects the antibody from proteolytic digestion)
11-What is the actual meaning of Fc and Fab ?
(These are the two portions of immunoglobulins produced after proteolytic cleavage of immunoglobulin. Fc denotes fragment crystallisable and Fab denotes antigen binding fragment)
12-Which form of Ig M – monomeric or polymeric acts as a receptor on the surface of B lymphocytes.
( Monomeric form)
13-Which form (Alpha helical, Beta pleated sheet or triple helical) predominates in the structure of collagen?                                    
(Triple helical)
14-What are the different types of heavy chains present in different types if immunoglobulins?
(α, β,γ,δ, Σ)
15-What types of globin chains  are present in Fetal Hemoglobin?
(Two alpha and 2 Gamma)
16-What is methaemoglobin?
( Hb in which iron is in the oxidized form(Ferric form )
17-25 % of the structure of hemoglobin is in the alpha helical form- state true or false?
(False- 75% is in the alpha helical form)
18-Name the beta globulins of biological significance
(Transferrin, Haemopexin, Complement etc)
19-What is the nature of ceruloplasmin?
(Alpha 2 globulin)
20-What is the function of Transferrin?
(Transfer of iron)
21-What is the function of fibrinogen?
(Blood clotting and viscosity)
22-What is the clinical significance of C- reactive protein ?
(Acute phase protein, activates complement, also helps in the formation of haem)

------------------------------------------ Best Wishes: Dr.Ehab Aboueladab, Tel:01007834123, ------------------------------------------