Questions Biochemistry

Q.-1- All amino acids except one participate in phase 2 reactions of detoxification
a) Serine
b) Glycine
c) Glutamine
d) Cysteine
(a)
Q.2- Which out of the following pathways helps in reductive biosynthesis
a) Uronic acid pathway
b) HMP pathway
c) Glycolysis
d) All of the above
(b)
Q.3- All of the following clinical manifestations except one are present in hemochromatosis-
a) Bronze discoloration of skin
b) Diabetes mellitus
c) Iron overload
d) Hemolytic anemia
(d)
Q.4- A person on ingestion of Primaquine develops hemolytic anemia, what is the possible defect?
a) Deficiency of Iron
b) Vitamin K deficiency
c) Glucose-6-P dehydrogenase deficiency
d) Vitamin C deficiency
(c)
Q.5- The enzyme responsible for conversion of Biliverdin to Bilirubin is-
a) Bilirubin esterase
b) Bilirubin oxidase
c) Glucuronyl transferase
d) Biliverdin reductase
(d)
Q.6-Biotin is involved in which of the following types of reactions-
a) Deamination
b) Decarboxylation
c) Carboxylation
d) Transamination
(c)
Q.7-The Xanthurenic acid test (Xanthurenic index) can be used to measure pyridoxine deficiency, it involves the metabolism of-
a) Glycine
b) Histidine
c) Tryptophan
d) Tyrosine
(c)
Q.8-McArdle’s disease is characterized by the deficiency of-
a) Muscle phosphorylase
b) Liver phosphorylase
c) Glucose-6-phosphatse
d) Phosphofructokinase
(a)
 Q.9-Out of 24 mols of ATP formed in citric acid cycle, 2 mols of ATP can be formed at substrate level by which of the following reaction?
a) Citrate——> Isocitrate
b) Isocitrate——–>Oxalo succinate
c) Succinate——->  Fumarate
d)Succinyl co A–> Succinate
(d)
 Q.10- All of the following metabolic abnormalities are observed in Diabetes mellitus, except-
a) Increase plasma free fatty acids
b) Increased pyruvate carboxylase activity
c) Decreased PDH complex activity
d) Increased lipoprotein lipase activity
(d)
Q.11-Beta oxidation of odd chain fatty acids yields

a) Succinyl co A
b) Propionyl co A
c) Acetoacetyl co A
d) Dicarboxylic acids
(b)
 Q.12-Iron therapy is ineffective in which of the following conditions-
a) Chronic blood loss
b) Inadequate iron intake
c) Thalassemia major
d)Acute blood loss
(c)
Q.13-Which of the following vitamins is not a component of electron transport chain-
a) Nicotinamide
b) Ubiquinone
c) Biotin
d) Riboflavin
(c)
Q.14-Which of the following enzymes does not have an impaired activity in Vitamin B1 deficiency?
a) Succinatedehydrogenase
b) Pyruvate dehydrogenase
c) Transketolase
d) Alpha keto glutarate dehydrogenase
(a)
Q.15- Considering the citric acid cycle steps between alpha keto glutarate and Malate, how many high-energy phosphate bonds or net ATP molecules can be generated?
a) 5
b) 6
c) 8
d) 10
(b)
Q.16- The standard free energy change (in terms of net ATP production) when glucose is converted to 6CO2 and 6H2O is about how many times as great as the free energy change when glucose is converted to  two lactate molecules ?
a) 2
b) 4
c) 19
d) 10
(c)
Q.17- The rate of flow of electrons through the electron transport chain is regulated by
a)ATP:ADP ratio
b) Concentration of Acetyl co A
c) Feed back inhibition by H2O
d) Catalytic rate of cytochrome oxidase
(a)
 Q.18- The major product of fatty acid synthase complex is-
a) Oleate
b) Palmitate
c) Palmityl co A
d) Stearoyl co A
(b)
Q.19- The primary enzyme for utilization of ketone bodies is-
a) Thiokinase
b) Thioesterase
c) Thiophorase
d) Thiolase
(c)
Q.20-All of the following processes except one are mitochondrial-
a) Glycolysis
b) TCA cycle
c) Beta oxidation of fatty acids
d) Ketogenesis
(a)


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