Archive for the ‘Proteomics’ Category

Pancreatic cancer genomes: Axon guidance pathway genes – aberrations revealed

Posted in Biological Networks, Gene Regulation and Evolution, Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, Chemical Genetics,Computational Biology/Systems and Bioinformatics, Genome Biology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, Genomic Testing: Methodology for Diagnosis, Liver & Digestive Diseases Research, Medical and Population Genetics, Metabolomics, Molecular Genetics & Pharmaceutical, Personalized Medicine & Genomic Research, Population Health Management, Nutrition and Phytochemistry, Proteomics, Statistical Methods for Research Evaluation, Technology Transfer: Biotech and Pharmaceutical, tagged cancer, Disease and Conditions, Garvan Institute of Medical Research, KRAS, Nature (journal), Pancreatic cancer on October 24, 2012 | Leave a Comment »

Reporter: Aviva Lev-Ari, PhD, RN     Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes   Andrew V. Biankin, Nicola Waddell, Karin S. Kassahn, Marie-Claude Gingras, Lakshmi B. Muthuswamy, Amber L. Johns, David K. Miller, Peter J. Wilson, Ann-Marie Patch, Jianmin Wu, David K. Chang, Mark J. Cowley, Brooke B. Gardiner, Sarah Song, Ivon Harliwong, Senel [...]

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Dopamine Gene Variant Predictive of Placebo Response in IBS Patients

Posted in Biological Networks, Gene Regulation and Evolution, Biomarkers & Medical Diagnostics, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, Chemical Genetics, Clinical Trials and IRB related issues,Computational Biology/Systems and Bioinformatics, Disease Biology, Small Molecules in Development of Therapeutic Drugs, FDA Regulatory Affairs, Genome Biology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, Genomic Testing: Methodology for Diagnosis, Human Immune System in Health and in Disease,Liver & Digestive Diseases Research, Medical and Population Genetics, Metabolomics,Molecular Genetics & Pharmaceutical, Nutrigenomics, Personalized Medicine & Genomic Research, Pharmaceutical R&D Investment, Proteomics, Technology Transfer: Biotech and Pharmaceutical, tagged Clinical trial, Beth Israel Deaconess Medical Center, Genetic marker, PLoS ONE, Catechol-O-methyl transferase, Irritable bowel syndrome, Placebo on October 24, 2012 | Leave a Comment »

Reporter: Aviva Lev-Ari, PhD, RN   Study Finds Dopamine Gene Variant Predictive of Placebo Response in IBS Patients October 24, 2012   By Molika Ashford Researchers led by a group at Beth Israel Deaconess Medical Center have identified a genetic marker associated with the placebo effect in patients with irritable bowel syndrome. According to the group, the [...]

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Metabolite Identification Combining Genetic and Metabolic Information: Genetic association links unknown metabolites to functionally related genes

Posted in Biological Networks, Gene Regulation and Evolution, Biomarkers & Medical Diagnostics, Cardiovascular Pharmaceutical Genomics, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, Chemical Genetics,Computational Biology/Systems and Bioinformatics, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Genome Biology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, Genomic Testing: Methodology for Diagnosis, Liver & Digestive Diseases Research, Medical and Population Genetics, Metabolomics, Molecular Genetics & Pharmaceutical, Origins of Cardiovascular Disease, Personalized Medicine & Genomic Research, Pharmaceutical R&D Investment,Population Health Management, Genetics & Pharmaceutical, Proteomics, Statistical Methods for Research Evaluation, Technology Transfer: Biotech and Pharmaceutical, tagged Research Triangle Park, Genome-wide association study, Helmholtz Zentrum München on October 22, 2012 | 1 Comment »

Reporter: Aviva Lev-Ari, PhD, RN  Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information Jan Krumsiek1, Karsten Suhre1,2, Anne M. Evans3, Matthew W. Mitchell3, Robert P. Mohney3, Michael V. Milburn3, Brigitte Wägele1,4, Werner Römisch-Margl1, Thomas Illig5,6, Jerzy Adamski7,8, Christian Gieger9, Fabian J. Theis1,10, Gabi Kastenmüller1*   1 Institute of Bioinformatics [...]

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Advances in Separations Technology for the “OMICs” and Clarification of Therapeutic Targets

Posted in Pharmaceutical Industry Competitive Intelligence, Personalized Medicine & Genomic Research, International Global Work in Pharmaceutical, Pharmaceutical R&D Investment, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Computational Biology/Systems and Bioinformatics, Genome Biology,Chemical Biology and its relations to Metabolic Disease, Biological Networks, Gene Regulation and Evolution, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Population Health Management, Genetics & Pharmaceutical, Alzheimer's Disease,Pharmacotherapy, Proteomics, Bio Instrumentation in Experimental Life Sciences Research, Biomarkers & Medical Diagnostics, Metabolomics, Nutrition, Nutrigenomics,Population Health Management, Nutrition and Phytochemistry, Molecular Genetics & Pharmaceutical, Technology Transfer: Biotech and Pharmaceutical, Imaging-based Cancer Patient Management, Nanotechnology for Drug Delivery, tagged ABPP, activity-based probes, adenosine-affinity chromatography, Affinity Chromatography, Aptamer affinity chromatography, Aptamer-based delivery system, Aptamer-based multiplexed technology, Biomarker discovery, BRCT domains, disease, drug discovery, expanded DNA alphabet, g-secretase, health, KIAA1362, metabolism, Metabolomics, Nutrigenomic,Nutrition, Omics, presenilin-like proteases, Proteomics, Pyruvate Kinase, selective inhibitors, signal peptide peptidases on October 22, 2012 | 1 Comment »

Curator, Reporter, EAW:  Larry H Bernstein, MD, FCAP Advances in Separations Technology for the “OMICs” and Clarification of Therapeutic Targets This discussion is a continuation of an earlier piece on the technologic framework for , proteomics, nutrigenomics, and translational medicine. The last decade has seen the emergence of a genomic science that is changing the [...]

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A Prion Like-Protein, Protein Kinase Mzeta and Memory Maintenance

Posted in Cell Biology, Signaling & Cell Circuits, Genome Biology, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Alzheimer's Disease, Proteomics,Innovations in Neurophysiology & Neuropsychology, tagged Ebonyi StateUniversity, Prion,protein kinase, memory, learning, neuronal plasticity, behavioral performance, neuronal astrocyte, memory encoding, synaptic function on October 19, 2012 | Leave a Comment »

Larry H Bernstein, MD, FCAP, Reporter An interesting paper recently published. I only show abstract and part of introduction. Available online http://www.interesjournals.org/JMMS Copyright © 2012 International Research Journals Review Martin Ezeani, Maxwell Omabe, J.C. Onyeanusi, I.N. Nnatuanya, Elom S.O. *1Department of Neurosciences, University of Sussex UK *2Molecular Pathology Division, Department of Medical Laboratory Sciences, Faculty [...]

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Gene Trap Mutagenesis in Reproductive Research

Posted in Pharmaceutical Analytics, Pharmaceutical Industry Competitive Intelligence,Personalized Medicine & Genomic Research, Pharmaceutical R&D Investment, Chemical Genetics, Cell Biology, Signaling & Cell Circuits, Computational Biology/Systems and Bioinformatics, Medical and Population Genetics, Genome Biology, Biological Networks, Gene Regulation and Evolution, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Population Health Management, Genetics & Pharmaceutical,Reproductive Biology & Bio Instrumentation, Proteomics, Bio Instrumentation in Experimental Life Sciences Research, Biomarkers & Medical Diagnostics, Molecular Genetics & Pharmaceutical, Stem Cells for Regenerative Medicine, Genomic Testing: Methodology for Diagnosis, Technology Transfer: Biotech and Pharmaceutical, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, taggedgene, genetics, genome, mutation, microarray, DNA, Nucleic acid sequence, reproductive research, gene trap mutagenesis, Dr. Sudipta Saha, Single-nucleotide polymorphism on October 18, 2012 | 1 Comment »

Reporter and Curator: Dr. Sudipta Saha, Ph.D. With the completion of the mapping of the human genome, we now have access to all the DNA sequence information responsible for human biology. Together with microarray technology, we are ushering in a new era in reproductive medicine—the era of Reproductive Genomics. Whole genome microarray analysis of the [...]

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Is the Warburg Effect the cause or the effect of cancer: A 21st Century View?

Posted in Biological Networks, Gene Regulation and Evolution, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Genome Biology, Imaging-based Cancer Patient Management, International Global Work in Pharmaceutical, Liver & Digestive Diseases Research, Metabolomics, Molecular Genetics & Pharmaceutical,Nutrition, Pharmaceutical Industry Competitive Intelligence, Pharmaceutical R&D Investment, Population Health Management, Genetics & Pharmaceutical, Population Health Management, Nutrition and Phytochemistry, Proteomics, Stem Cells for Regenerative Medicine, Technology Transfer: Biotech and Pharmaceutical, tagged Adenosine triphosphate, ATP, Glycolysis, Hypoxia-inducible factors, Kreb, Lactate dehydrogenase,Mammalian target of rapamycin, Mitochondrion, Warburg Effect on October 17, 2012 | 6 Comments »

Is the Warburg Effect the cause or the effect of cancer: A 21st Century View?   Larry H. Bernstein, MD,, FCAP, Curator, EAW, A Critical Review   What is the Warburg effect? “Warburg Effect” describes the preference of glycolysis and lactate fermentation rather than oxidative phosphorylation for energy production in cancer cells. Mitochondrial metabolism is [...]

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Statins’ Nonlipid Effects on Vascular Endothelium through eNOS Activation

Posted in 'Nitric Oxide in Health and Disease', Biological Networks, Gene Regulation and Evolution, Cardiovascular Pharmaceutical Genomics, Cell Biology, Signaling & Cell Circuits, Disease Biology, Small Molecules in Development of Therapeutic Drugs, HTN,Metabolomics, Molecular Genetics & Pharmaceutical, Origins of Cardiovascular Disease,Pharmacotherapy Cardiovascular Disease, Pharmacotherapy of Cardiovascular Disease,Proteomics, tagged eNOS, vascular relaxation, vasorelaxation, micro and macrocirculationon October 8, 2012 | 7 Comments »

Curator, Author,Writer, Reporter: Larry Bernstein, MD, FCAP   Categories of Research: Disease biology, Cell Biology and Cell Signaling, Biological Networks and Gene Regulation, Pharmacotherapy of Cardiovascular Disease, Nitric Oxide, HMG Co A inhibitors, Endothelial Receptor, Hypertension, Therapeutic Targets Introduction Statins have an effect on the vascular endothelium, which plays an important role in the development [...]

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Expanding the Genetic Alphabet and linking the genome to the metabolome

Posted in Pharmaceutical Analytics, Pharmaceutical Industry Competitive Intelligence,Personalized Medicine & Genomic Research, Pharmaceutical R&D Investment, CANCER BIOLOGY & Innovations in Cancer Therapy, Chemical Genetics, Cell Biology, Signaling & Cell Circuits, Computational Biology/Systems and Bioinformatics, Medical and Population Genetics, Genome Biology, Chemical Biology and its relations to Metabolic Disease,Biological Networks, Gene Regulation and Evolution, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Population Health Management, Genetics & Pharmaceutical, Liver & Digestive Diseases Research, Proteomics, Bio Instrumentation in Experimental Life Sciences Research, Biomarkers & Medical Diagnostics, Metabolomics,Nutrition, Nutrigenomics, Population Health Management, Nutrition and Phytochemistry,Systemic Inflammatory Response Related Disorders, Molecular Genetics & Pharmaceutical, Genomic Testing: Methodology for Diagnosis, Technology Transfer: Biotech and Pharmaceutical, Scientist: Career considerations, tagged adenine, ATP,biodiversity, cancer, Cancer Genome Atlas, cystathionine beta synthase, cytosine, DNA,fumarate, gene modification, genetic code, genetic engineering, genetics, genome,guanine, H2S, homocysteine, inosine, malnutrition, metabolome, methionine, Nature (journal), Nature Chemical Biology, Nucleic acid double helix, nucleosides, oncometabolite,oxidative stress, proteome, regulatory pathways, S-adenosylmethionine, Scripps Research Institute, Sulfur, synthetic nucleotides, thymidine, Warburg Effect, Watson-Crick Model,xanthine on September 24, 2012 | 6 Comments »

Reporter: Curator (Nutrigenomic and Nutriceuticals) Larry Bernstein, MD, FACP Unlocking the diversity of genomic expression within tumorigenesis and “tailoring” of therapeutic options   1. Reshaping the DNA landscape between diseases and within diseases by the linking of DNA to treatments In the NEW York Times of 9/24,2012 Gina Kolata reports on four types of breast [...]

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NATIONAL CENTERS FOR BIOMEDICAL COMPUTING: Resources

Posted in Bio Instrumentation in Experimental Life Sciences Research, Biomarkers & Medical Diagnostics, Cell Biology, Signaling & Cell Circuits, Computational Biology/Systems and Bioinformatics, FDA Regulatory Affairs, Genome Biology, Genomic Testing: Methodology for Diagnosis, Molecular Genetics & Pharmaceutical, Personalized Medicine & Genomic Research, Population Health Management, Genetics & Pharmaceutical,Proteomics, Scientist: Career considerations, Statistical Methods for Research Evaluation,Technology Transfer: Biotech and Pharmaceutical, tagged genetics, genomics, National Institutes of Health, Aviva Lev-Ari, Brigham and Women's Hospital, Biology, Stanford University, systems biology, Bioinformatics, National Centers for Biomedical Computing,Cellular network on September 20, 2012 | Leave a Comment »

  Reporter: Aviva Lev-Ari, PhD, RN NATIONAL CENTERS FOR BIOMEDICAL COMPUTING An overarching approach to several disciplines: Genomics Major research areas of Genomics: 2.1 Bacteriophage genomics 2.2 Cyanobacteria genomics 2.3 Human genomics 2.4 Metagenomics 2.5 Pharmacogenomics Other Genomics related subdisciplines: Computational genomics Epigenomics Whole genome sequencing Functional genomics Genomics of domestication Immunomics Metagenomics Nitrogenomics Personal genomics Proteomics Psychogenomics The Biomedical Computing [...]

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