Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes

Title
Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes
Authors
Bettina Brandt, Tom Büchse, Ehab Fathi Abou-Eladab, Markus Tiedge, Eberhard Krause, Udo Jeschke, Hermann Walzel
Publication date
2008/5/1
Journal name
Histochemistry and cell biology
Volume
129
Issue
5
Pages
599-609
Publisher
Springer Berlin/Heidelberg
Description
Abstract Galectin-1 (gal-1), a member of the family of ?-galactoside binding proteins,
participates in several biological processes such as immunomodulation, cell adhesion,
regulation of cell growth and apoptosis. The aim of this study was to investigate whether gal-
1 interferes with the Fas (Apo-1/CD95)-associated apoptosis cascade in the T-cell lines
Jurkat and MOLT-4. Gal-1 and an Apo-1 monoclonal antibody (mAb) induced DNA-
fragmentation in Jurkat T-cells whereas MOLT-4 cells were resistant. Gal-1 stimulated ...


------------------------------------------ Best Wishes: Dr.Ehab Aboueladab, Tel:01007834123 Email:ehab10f@gmail.com,ehababoueladab@yahoo.com ------------------------------------------