Impact of Sildenafil on Smooth Muscle and Blood Vessels by Using Light and Electron Microscopy

British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 16, Issue.: 8

Original Research Article

Impact of Sildenafil on Smooth Muscle and Blood Vessels by Using Light and Electron Microscopy

Ehab Abou-eladab^1,2*, Heba Abd Alrazzak abd Alfattah² and Faten Shehata²

¹Damietta University, Faculty of Specific Education, New Damietta City, Egypt.

²Alfarabi College for Dentistry and Nursing, Basic Science Department, Jeddah, Saudi Arabia.

Abstracts

The present study aimed to examine the histological changes in the smooth muscles of corpus cavernosum and veins of rats as an eventual outcome of the ceaseless use of Sildenafil citrate. The comparison of the histological aftereffects of the veins among the control and experimental groups revealed extended thickness of tunica intima and media, as exhibited by a picture analyzer. The findings indicated that the steady usage of Sildenafil reduced smooth muscles and enabled the growth of collagen fibers in corpus cavernosum of penis and mass of veins.

Keywords :

Sildenafil citrate; continuous use; corpus cavernosum; blood vessels.

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